Metronidazole Extended Release Solid Dosage Form: Development of extended release formulation and in vitro bioequivalence study of Metronidazole solid dosage form

Currently two effective ways are used with the administration of a metronidazole composition. A single, large dose is given as a bolus to the patient which is clinically effective but a major drawback to the administration of single large dose of metronidazole is the occurrence of significant and undesirable side effects. A second and more generally accepted treatment entails orally administering smaller dose of metronidazole three time a day. The lower dosage of metronidazole over a period of a week significantly reduces the occurrence and severity of side effect but patient compliance is a problem can inadvertently forget to take one or more doses during the course of treatment, causing the plasma metronidazole level drop to bellow an acceptable therapeutic level for a period of several hours or more. Hence extended release formulation of metronidazole could be suitable alternative for reducing the number of daily doses needed to treat a microbial infection, while maintaining the benefit of making bioavailable effective amount of drug over an extended time period.

Studied MS in Pharmaceutical Science at Jahangirnagar University, Bangladesh. Earlier, he completed Bachelor of Pharmacy from the same institution. He is now working with Square Pharmaceutical Ltd., Bangladesh as Executive at Production department and also worked with Beximco Pharmaceuticals Ltd., Bangladesh as Quality Assurance Officer.