Metronidazole Floating Microspheres: Preparation, Evaluation and Optimization of Metronidazole Floating Microspheres

Patel, Kalpen, Patel, Garvit, Patel, Maulika

ISBN 10: 3659312207 / ISBN 13: 9783659312205

Published by LAP LAMBERT Academic Publishing, 2012

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Bibliographic Details

• Title: Metronidazole Floating Microspheres: Preparation, Evaluation and Optimization of Metronidazole Floating Microspheres
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3659312207
• ISBN 13: 9783659312205
• Binding: Paperback
• Condition: Like New
• Book Type: book

About this title

Synopsis

Gastroretentive systems can remain in the gastric region for several hours and hence significantly prolong the gastric residence time of drugs. Prolonged gastric retention improves bioavailability, reduces drug waste, and improves solubility for drugs that are less soluble in a high pH environment. Floating microspheres are especially effective in delivery of sparingly soluble and insoluble drugs. It is known that as the solubility of a drug decreases, the time available for drug dissolution becomes less adequate and thus the transit time becomes a significant factor affecting drug absorption. For weakly basic drugs that are poorly soluble at an alkaline pH, hollow microspheres may avoid chance for solubility to become the rate-limiting step in release by restricting such drugs to the stomach.

About the Author

KALPEN N PATEL, M. PHARM. in Pharmaceutical Technology Studied at the Shree Krishna Institute of Pharmacy, Shankhalpur, Mehsana, Gujarat.