MicroRNA Regulation of Dendritic Cells | Experimental studies on the role of microRNAs in dendritic cell development and function

Frauke Marie Schnorfeil

ISBN 10: 3838131894 / ISBN 13: 9783838131894

Published by Südwestdeutscher Verlag für Hochschulschriften, 2015

About this Item

MicroRNA Regulation of Dendritic Cells | Experimental studies on the role of microRNAs in dendritic cell development and function | Frauke Marie Schnorfeil | Taschenbuch | 88 S. | Englisch | 2015 | Südwestdeutscher Verlag für Hochschulschriften | EAN 9783838131894 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 106590597

Bibliographic Details

• Title: MicroRNA Regulation of Dendritic Cells | Experimental studies on the role of microRNAs in dendritic cell development and function
• Publisher: Südwestdeutscher Verlag für Hochschulschriften
• Publication Date: 2015
• Language: English
• ISBN 10: 3838131894
• ISBN 13: 9783838131894
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 6D millimeters 220 millimeters width by 150 millimeters height by 6 millimeters depth
• Weight: 149 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

Dendritic cells (DCs) play a key role in the initiation of adaptive immune responses and the maintenance of immunological self-tolerance. Due to their therapeutic potential, understanding the mechanisms that guide DC differentiation and effector functions is important. The recent identification of posttranscriptional control of gene expression by microRNAs has added a novel layer of gene regulation that may be important in DC biology. The experimental work presented and discussed here indicates a role for microRNAs in DC regulation that is not covered by transcription factors. An essential role for microRNAs in DC lineage fate decisions, as well as in homeostasis, maturation and function of Langerhans cells (the epidermal DCs) is demonstrated. Thus, microRNAs regulate various aspects of DC biology and thereby contribute to the control of adaptive immune responses.

About the Author

Frauke Marie Schnorfeil, Dr. rer. nat., studied Biology focusing on Human Genetics and Immunology. In 2011, she received her doctoral degree from the LMU Munich, Germany, for her research on dendritic cells.