Microarray Analysis on Alzheimer*s Disease: An approach towards gene expression study using R Language and Biocondcutor

Tripathi, Sweta, Gor, Ravi, Pandya, Himanshu

ISBN 10: 3659173754 / ISBN 13: 9783659173752

Published by LAP LAMBERT Academic Publishing, 2012

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Bibliographic Details

• Title: Microarray Analysis on Alzheimer*s Disease: An approach towards gene expression study using R Language and Biocondcutor
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3659173754
• ISBN 13: 9783659173752
• Binding: Paperback
• Condition: Like New
• Book Type: book

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Synopsis

Microarray technology is a novel technique to identify the Evaluation of differentially expressed gene.This is very useful for the stastical analysis of DNA chip using different stastical software’s.This work is attempted to work on microarray analysis on Alzheimer’s disease and identify the differentially expressed gene and their reannotation using R and Biocondcutor.R language is freely available and its latest release is Biocondcutor Software. Here,R language and Biocondcutor software is used for the stastical analysis of hippocampus sample of Alzheimer’s disease.The data get normalized using RMA and GCRMA generated different Box plot, Nuse plot, RLE Plot and clustering analysis. Using Biocondcutor different stastical test is a best proof for identify the gene expression level of gene.After annotation identify the gene which were responsible for Alzheimer’s disease.The Biocondcutor and R language gives basically identify the main probe which is responsible in that sample for disease and gives the final result which caused the Alzheimer’s disease.

About the Author

Sweta Tripathi is a Bioinformatician completed her post graduate degree in Bioinformatics from Gujarat University, Ahmedabad, India.Completed Research work on Microarray data Analysis on Alzheimer's disease Using R and Biocondcutor.Now,presently she is working on Drug prediction for the Alzheimer’s disease and Web-Development tool.