Microdialysis in Drug Development

Markus Müller

ISBN 10: 146144814X / ISBN 13: 9781461448143

Published by Springer New York, Springer US, 2012

About this Item

Druck auf Anfrage Neuware - Printed after ordering - In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development.

Seller Inventory # 9781461448143

Bibliographic Details

• Title: Microdialysis in Drug Development
• Publisher: Springer New York, Springer US
• Publication Date: 2012
• Language: English
• ISBN 10: 146144814X
• ISBN 13: 9781461448143
• Binding: Buch
• Condition: Neu
• Dimensions: 241W x 160H x 22D millimeters 241 millimeters width by 160 millimeters height by 22 millimeters depth
• Weight: 693 grams

About this title

Synopsis

A vast number of diagnostic and therapeutic decisions are based on measuring blood concentrations of molecules, yet most biochemical and pharmacological events actually take place in the tissues. Microdialysis is a key semi-invasive sampling technique to measure in vivo drug penetration to the target site in humans, the method being feasible in virtually every organ. Authored by international experts in this cutting edge field, this book will provide a comprehensive overview of microdialysis and its application for measuring drug distribution in drug development.

About the Author

Prof. Markus Müller, MD is Head of the Department of Clinical Pharmacology at the Medical University of Vienna in Austria. He is specialized in Internal Medicine and Clinical Pharmacology and is an international expert in clinical research. He has published over 80 articles on the use and methodology of microdialysis in clinical drug development.