Microfluidics and BioMEMS: Devices and Applications

The past two decades have seen rapid development of micro-/nanotechnologies with the integration of chemical engineering, biomedical engineering, chemistry, and life sciences to form bio-MEMS or lab-on-chip devices that help us perform cellular analysis in a complex micro-/nanoflluidic environment with minimum sample consumption and have potential biomedical applications. To date, few books have been published in this field, and researchers are unable to find specialized content. This book compiles cutting-edge research on cell manipulation, separation, and analysis using microfluidics and bio-MEMS devices. It illustrates the use of micro-robots for biomedical applications, vascularized microfluidic organs-on-a-chip and their applications, as well as DNA gene microarray biochips and their applications. In addition, it elaborates on neuronal cell activity in microfluidic compartments, microvasculature and microarray gene patterning, different physical methods for drug delivery and analysis, micro-/nanoparticle preparation and separation in a micro-/nanofluidic environment, and the potential biomedical applications of micro-/nanoparticles. This book can be used by academic researchers, especially those involved in biomicrofluidics and bio-MEMS, and undergraduate- and graduate-level students of bio-MEMS/bio-nanoelectromechanical systems (bio-NEMS), biomicrofluidics, biomicrofabricatios, micro-/nanofluidics, biophysics, single-cell analysis, bionanotechnology, drug delivery systems, and biomedical micro-/nanodevices. Readers can gain knowledge of different aspects of microfluidics and bio-MEMS devices; their design, fabrication, and integration; and biomedical applications. The book will also help biotechnology-based industries, where research and development is ongoing in cell-based analysis, diagnosis, and drug screening.

Tuhin S. Santra is assistant professor at the Department of Engineering Design, Indian Institute of Technology Madras, India, and also a tenure track visiting professor at National Tsing Hua University, Taiwan, since 2018. He obtained his PhD in bio-NEMS from National Tsing Hua University in 2013. He was a postdoctoral researcher at the University of California, Los Angeles, from 2015 to 2016 and visiting professor at the University of Cambridge, UK, in 2019. He is also a Wellcome Trust/DBT India Alliance fellow and serves as a guest editor for many journals, such as Cells and the International Journal of Molecular Science. Dr. Santra has edited five books, and his main research areas include bio-MEMS and bio-NEMS, single-cell analysis, biomedical micro-/nanodevices, cell chips, and nanomedicine.