Microsponge Based Colonic Drug Delivery Systems: Development and Characterization of Microsponge Based Colonic Drug Delivery Systems

Jain, Vikas, (Dr.) Ranjit Singh, Prof.

ISBN 10: 3838394178 / ISBN 13: 9783838394176

Published by LAP LAMBERT Academic Publishing, 2010

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Bibliographic Details

• Title: Microsponge Based Colonic Drug Delivery Systems: Development and Characterization of Microsponge Based Colonic Drug Delivery Systems
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2010
• Language: English
• ISBN 10: 3838394178
• ISBN 13: 9783838394176
• Binding: Paperback
• Condition: Like New
• Book Type: book

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Synopsis

This study encompasses preparation microsponges based colon specific tablet formulations. Initially, microsponges of dicyclomine and paracetamol were prepared by quasi-emulsion solvent diffusion method. The reason for preparing microsponge due to the fact that, drug carrier systems less than 200 ?m may efficiently be taken up by the macrophages present in colon tissue, thus exhibit effective localized drug action at the desired site. A subsequent increase of residence time that may be postulated for microsponges as compared to existing drug delivery systems may allow dose reduction and enhance therapeutic effect. Another reason for preparing microsponges was their sponge like texture that can easily be compressed by direct compression for producing mechanically strong tablets. Then core tablets of microsponges were prepared by direct compression method and were compression coated with pectin:HPMC mixture. The reason for selecting pectin was its biodegradation in the colon by colonic flora. HPMC is reported to increase the mechanical strength of the tablet coat and helped in maintaining its integrity during its sojourn in the gastro-intestinal tract.

About the Author

Dr. Vikas Jain obtained his Ph.D. in 2010 from Shobhit University, Meerut, Uttar Pradesh, India. He has more than 07 publications to his credit in journals of repute and many presentations in International and National Conferences. Dr. Jain has contributed immensely in the field of Microsponge based Novel Drug Delivery Systems.