Title: Mitochondriale Biogenese in der Pathogenese der Endometriose: Die Rolle der mitochondrialen DNA-Kopienzahl bei Endometriose (German Edition)
Publisher: Verlag Unser Wissen
Publication Date: 2024
Language: German
ISBN 10: 6207729625
ISBN 13: 9786207729623
Binding: Soft cover
Condition: New

About this title

Synopsis

Bei der Endometriose handelt es sich um eine �strogenabh�ngige Erkrankung, die bei Frauen im reproduktiven Alter ein abnormales Wachstum von endometrium�hnlichem Gewebe au�erhalb der Geb�rmutterh�hle aufweist. Sch�tzungen zufolge sind weltweit 5-10 % der Frauen im reproduktiven Alter davon betroffen. Eine gest�rte mitochondriale Biogenese und eine durch oxidativen Stress ausgel�ste Entz�ndungsreaktion in der Beckenh�hle werden mit der Pathogenese der Endometriose in Verbindung gebracht. Da es sich bei der Endometriose um eine mit Entz�ndungen und dem Energiestoffwechsel assoziierte Erkrankung handelt und die Gene TFAM, PGC-1α und VDR an der Aufrechterhaltung der mitochondrialen DNA-Integrit�t und Kopienzahl beteiligt sind, wird die Analyse der Polymorphismen von TFAM, PGC-1α und VDR in Bezug auf die mitochondriale DNA-Kopienzahl zum besseren Verst�ndnis der Pathophysiologie der Endometriose beitragen.

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