Modelling of the Cell-Mediated Immune Response to Epstein Barr Virus: Bioinformatics and Systems Biology, an Application of Computer to the Study of Host-Pathogen Interaction

Agyemang, Alex Adusei

ISBN 10: 3848411911 / ISBN 13: 9783848411917

Published by LAP LAMBERT Academic Publishing, 2012

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Bibliographic Details

• Title: Modelling of the Cell-Mediated Immune Response to Epstein Barr Virus: Bioinformatics and Systems Biology, an Application of Computer to the Study of Host-Pathogen Interaction
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3848411911
• ISBN 13: 9783848411917
• Binding: Paperback
• Condition: Like New
• Book Type: book

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Synopsis

Epstein Barr is a virus that infects the B cells of the immune system expressing certain proteins that can cause the B lymphocytes to escape apoptosis leading to lymphoma’s and others. The immune system reacts by producing armed effector Tcells that eliminate the infected lymphocytes. Due to the destructive nature of Tcells, its production must be monitored. In this paper, a model was built defining the various biochemical events leading to the priming of the T cell, giving a time series for the changes in the concentrations of all the species involved in T cell priming and deducing the species most relevant in the production of activated Tcells needed to wipe out this virus. To do this, literature containing detailed information on priming of T cell were collected from immunology books, journals and websites. A cartoon model describing the Tcell priming events was then built from the information gathered from literature.

About the Author

I offered BSc biochemistry at the kwame nkrumah university of science and technology,ghana which i graduated with a first class honours in the year 2010. right after, i served as a teaching and research assistant in the university for a year.i am currently in the process of pursuing postgraduate studies.