Modelling Proteasome Dynamics in a Bayesian Framework (BestMasters)

Sabine St�bler

ISBN 10: 3658201665 / ISBN 13: 9783658201661

Published by Springer Spektrum 2017-12-13, 2017

About this Item

Seller Inventory # 6666-IUK-9783658201661

Bibliographic Details

• Title: Modelling Proteasome Dynamics in a Bayesian Framework (BestMasters)
• Publisher: Springer Spektrum 2017-12-13
• Publication Date: 2017
• Language: English
• ISBN 10: 3658201665
• ISBN 13: 9783658201661
• Binding: Paperback
• Condition: New

About this title

Synopsis

Sabine Stübler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition.

About the Author

Sabine Stübler works as PhD student in the Computational Physiology Group at the Institute of Biochemistry and Biology, University of Potsdam. Her research focus currently is on developing a novel systems pharmacology model.