Modulation of HIV Co-Receptor Expression on Cells by Anti-Virals

Language: English

Published by LAP LAMBERT Academic Publishing Jun 2011, 2011

3844334246 / 9783844334241

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This item is printed on demand - Print on Demand Titel. Neuware -It is the cell surface molecule receptor CD4 and the two chemokine co-receptors CCR5 and CXCR4 that allow the Human Immunodeficiency Virus (HIV) to enter and infect target cells; these are the direct or indirect targets of anti-retroviral drugs (ARV) currently being tested in clinical trials. No characterisation of the potential effect of these drugs on the level of expression of the receptor and/or co-receptors on the cell surface has, as of yet been performed. This is despite the existence of heterologous modulation of at least CCR5 by compounds which are structurally similar to some ARV drugs. We investigated whether candidate microbicides could modulate the expression of CD4, CCR5 and/or CXCR4 on the cell surface membrane of various cell types. Cell lines expressing different or unknown levels of co-receptors were incubated with entry inhibitors, reverse transcriptase inhibitors and protease inhibitors in a time course mode before assessment by flow cytometry.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 92 pp. Englisch.

Seller Inventory # 9783844334241

Title
Modulation of HIV Co-Receptor Expression on Cells by Anti-Virals
Author
Daniel Y Adu
Publisher
LAP LAMBERT Academic Publishing Jun 2011
Publication year
2011
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3844334246
ISBN 13
9783844334241
Item weight
155 grams
Dimensions
220x150x6 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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