Modulation of Host Gene Expression and Innate Immunity by Viruses
Language: English
Published by Springer Netherlands, 2010
- Softcover
- New
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The interplay of host and virus represents one of the most significant frontiers in biology todayProvides a clearer understanding of the mechanisms involved to arm us with better strategies to deal with viruses, including emerging pathogens and po.
Seller Inventory # 5820673
- Title
- Modulation of Host Gene Expression and Innate Immunity by Viruses
- Author
- Changeux, Jean-Pierre|Palese, Peter
- Publisher
- Springer Netherlands
- Publication year
- 2010
- Condition
- New
- Binding
- Soft cover
- Language
- English
- ISBN 10
- 9048168236
- ISBN 13
- 9789048168231
This book is an excellent, up-to-date reference on a relatively young area of research in which virology, cellular biology and molecular pathogenesis govern the principles of coinvestigation. Thus, the book will be of great interest to virologists, molecular immunologists and biologists, and biochemists but also to clinical pharmacologists in the long-term search for new antiviral agents. Ulrich Desselberger, Gif-sur-Yvette/Cambridge.
Infection of a naïve (non-immune) host with a virus elicits an immediate response which results in a cascade of changes in the host, including an interferon response (innate immunity). The outcome of this interaction is influenced by the genes of the virus as well as the genes of the host. Interestingly, different viruses do it in different ways. Not only is there a plethora of mechanisms used by the invading organisms, but the host has also evolved a great variety of redundant and robust countermeasures. This interplay of host and virus represents one of the most significant frontiers in biology today. A clearer understanding of the mechanisms involved will arm us with better strategies to deal with viruses, including emerging pathogens and potential bioterrorism agents. This book is sure to benefit students, scientists, and physicians working in the areas of virology, immunology, microbiology, and infectious diseases. Pharmaceutical industry professionals will also find interest in this illuminating look into virus/host interactions.
"Synopsis" may belong to another edition of this title.
Review
While the molecular mechanisms of antibody production and diversity and of cellular specific immune responses have been studied since many decades, the actions of viruses blocking and modifying the innate immune system, i.e. mainly the interferon (IFN) response and its various signaling pathways, have been recognized and studied in more detail only during the last 10-15 years. Viruses can counteract defense strategies of infected cells, and specific proteins of many viruses were found to act as IFN antagonists.
In this book a number of groups leading this area of research have presented reviews and updates of their research. In the introductory chapter M Shaw and P Palese review the IFN signaling pathways and provide a comprehensive list of virus-encoded proteins that target different components of the pathways of the IFN response. It is then reviewed how viruses elicit the IFN production (DE Levy and IJ Marié), how IFN regulatory genes are induced by viruses (group of GC Sen), how viruses have ‘learned’ to evade immune mechanisms, interfering with MHC mediated antigen presentation, blockage of apoptosis, mimicking of cytokines and cellular receptors, or by direct infection of immune cells (group of HL Ploegh). In additional chapters, the virus-encoded IFN antagonists of particular viruses are described, such as of influenzaviruses (A Garcia-Sastre), paramyxoviruses (group of RE Randall), herpes simplex virus (SJ Advani and B Roizman), poxviruses (JB Johnston and G McFadden), filoviruses, bunyaviruses and flaviviruses (CF Basler). For poxviruses, the mechanisms of molecular mimikry, i.e. viral proteins binding to cytokines or cytokine receptors, are of particular interest. A new area of research is the involvement of toll-like receptors in the activation of pathways of the innate immune response and of their interaction with viral proteins (SR Ross). Autophagy is a protective mechanism of mammalian cells that can be targeted by viral virulence gene products (group of B Levine). Finally, the ways in which the genetic variation of hosts influences the susceptibility to viral infections is reviewed in a short chapter with particular attention to infection with HIV (E Choi and S Chanock).
There is minimal overlap between the different chapters, and the references are very up-to-date (a considerable number of them published in 2004). In several chapters the years of publication of references are omitted for no obvious reasons. Some chapters would have benefited from the presence of illustrations and tables.
This book is an excellent, up-to-date reference on a relatively young area of research in which virology, cellular biology and molecular pathogenesis govern the principles of coinvestigation. Thus, the book will be of great interest to virologists, molecular immunologists and biologists, and biochemists but also to clinical pharmacologists in the long-term search for new antiviral agents.
Gif-sur-Yvette/Cambridge,
Ulrich Desselberger
"About the title" may belong to another edition of this title.
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Moluna GmbH
Engberdingdamm 27
Greven, Germany 48268
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Instructions for revocation
Revocation right
You have the right to revoke this contract within one month without specifying any reasons.
The revocation period is one month with effect from the day,
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on which you or a third party nominated by you, which is not the carrier, had taken possession of the products, provided you had ordered one or more products within the scope of a standard order and this/these product/products is/are delivered uniformly;
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Specimen - revocation form
(If you wish to revoke the contract, please fill up this form and send it back to us.)
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To Moluna GmbH, Münsterstr. 105, 48268 Greven, Fax number: 02571/5 69 89 30, Email address: abe@moluna.de :
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I/we () herewith revoke the contract concluded by me/ us () regarding the purchase of the following products ()/
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Insofar as you are an entrepreneur, the following shall apply in deviation from the above warranty provisions:
a) Only our own specifications and the manufacturer's product description shall be deemed agreed as the quality of the goods, but not other advertising, public promotions and statements by the manufacturer.
b) In the event of defects, we shall, at our discretion, provide warranty by rectification of the defect or subsequent delivery. If the rectification of defects fails, you may, at your option, demand a reduction in price or withdraw from the contract. The rectification of defects shall be deemed to have failed after a second unsuccessful attempt, unless the nature of the goods or the defect or other circumstances indicate otherwise. In the event of rectification of defects, we shall not be obliged to bear the increased costs arising from the transport of the goods to a place other than the place of performance, unless such transport is in accordance with the intended use of the goods.
c) The warranty period shall be one year from delivery of the goods. The shortening of the period shall not apply
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(3) The provisions of the UN Convention on Contracts for the International Sale of Goods are explicitly inapplicable.
II. Customer information
- Identity of the seller
Moluna GmbH
Engberdingdamm 27
48268 Greven
Germany
Telephone: 02571/5698933
E-Mail: abe@moluna.de
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The technical steps associated with the conclusion of the contract, the contract conclusion itself and the correction options are executed in accordance to the regulations "conclusion of the contract" in our standard business terms (part I.).
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6.2 If you are a consumer, the following is statutorily regulated: The risk of the sold item accidentally being destroyed or degraded during shipping only passes over to you when the item in question is delivered, regardless of whether or not the shipping operation is insured. This condition does not apply if you have independently commissioned a transport company that has not been specified by us or a person who has otherwise been appointed to execute the shipping operation.
If you are a businessman, the delivery and shipping operations take place at your own risk.
- Statutory warranty right
Liability for defects is governed by the “Warranty” provisions in our General Terms and Conditions of Business (Part I).
last update: 01.01.2022
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last update: 10.01.2022