Modulation of protein-protein interactions

Altaf Dar

ISBN 10: 3843361789 / ISBN 13: 9783843361781

Published by LAP LAMBERT Academic Publishing Okt 2010, 2010

About this Item

This item is printed on demand - Print on Demand Titel. Neuware -Interaction of proteins is central to various cellular processes like cell growth, proliferation, differentiation and programmed cell death. To study the specific role of a single protein-protein interaction of a multifunctional protein or protein complex, it is necessary to interrupt each single interaction individually to elucidate their respective role and influence they exert. In this study two approaches were employed to modulate protein interactions. First one was to target a known protein-protein interaction by expressing specific peptides in vivo. The second one was based on the LXXLL motif to disrupt interactions between transcription factors and coactivators.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 96 pp. Englisch.

Seller Inventory # 9783843361781

Bibliographic Details

• Title: Modulation of protein-protein interactions
• Publisher: LAP LAMBERT Academic Publishing Okt 2010
• Publication Date: 2010
• Language: English
• ISBN 10: 3843361789
• ISBN 13: 9783843361781
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 7D millimeters 220 millimeters width by 150 millimeters height by 7 millimeters depth
• Weight: 161 grams

About this title

Synopsis

Interaction of proteins is central to various cellular processes like cell growth, proliferation, differentiation and programmed cell death. To study the specific role of a single protein-protein interaction of a multifunctional protein or protein complex, it is necessary to interrupt each single interaction individually to elucidate their respective role and influence they exert. In this study two approaches were employed to modulate protein interactions. First one was to target a known protein-protein interaction by expressing specific peptides in vivo. The second one was based on the LXXLL motif to disrupt interactions between transcription factors and coactivators.

About the Author

Altaf A Dar is currently working on identifying biomarkers involved in melanoma progression and metastasis at CPMC, San Francisco, CA. Previously Dr. Dar worked on gastric cancer at Vanderbilt University, Nashville, TN. Dr. Dar earned his PhD from Friedrich Schiller University, Jena Germany, where he worked on protein-protein interactions.