Molecular Biophysics of the Extracellular Matrix

Struther Arnott|D. A. Rees|E. R. Morris

ISBN 10: 0896030512 / ISBN 13: 9780896030510

Published by Humana Press, 1984

About this Item

1 Structure and Associations of Proteoglycans in Cartilage.- Structure.- Preparation.- Link-Free Aggregates.- Link-Stable Aggregates.- The Secretion and Assembly of Proteoglycan Aggregates.- Diversity of Proteoglycan Structure.- 2 The Dilute Solution Proper.

Seller Inventory # 458445897

Bibliographic Details

• Title: Molecular Biophysics of the Extracellular Matrix
• Publisher: Humana Press
• Publication Date: 1984
• Language: English
• ISBN 10: 0896030512
• ISBN 13: 9780896030510
• Binding: Gebunden
• Condition: New

About this title

Synopsis

Biopolymers, such as proteins and nucleic acids have been subjected to a rational succession of structural studies in which the determination of chemical compositions, link- ages, and sequences is followed by investigations of molecu- lar architecture and interactions. By the end of the 1960s the covalent structures of glycosaminoglycans and proteo- glycans had been defined both within the carbohydrate chains and in respect to their linkages to protein. The scene was therefore set for successful probing of three- dimensional shapes and intermolecular associations. For- tunately, during the 1970s appropriate physical methods were themselves greatly increasing in power. Consequently much progress has been made using X-ray diffraction anal- ysis of hydrated films, nuclear magnetic resonance spectro- scopy, and chromatographie methods for investigation of molecular interactions in solution. We now have a great deal of information about molecular shapes, their sensitiv- ity to environment (especially associated cations), and their modes of interaction that could be relevant to super- molecular assemblies in biological milieux. For these rea- sons we judged that it would be timely to distil the main conclusions from this phase of research to prepare for the next, which will involve detailed study of the interplay be- tween biological function and molecular structure. The idea for this volume emerged from a workshop meeting at Colworth sponsored by the Biochemical Society.