The Molecular Clock of Human Embryonic Heart: Human Embryonic Heart Development by the four main Genes

Today heart disease is very dangerous in humans. Because most heart disease is fatal to humans. Unfortunately, many human cardiovascular disease, caused by lack of proper development of heart muscle and heart cells in the fetus. Genes play a role in the development process of cardiovascular muscles that are important utero. In this book, the four main genes PEP,FNDC5,C2C12,PGC1α play an important role in the development of heart cells and cardiovascular muscles have studied.FNDC5 gene with another protein called Xuemei Proxy (PEP) is a 209 amino acid protein coding. These genes mainly in heart tissue, skeletal muscle and brain expressed. This study aimed to clarify the pattern of expression of this gene in mouse embryonic cells Heart cells taken. The mouse embryonic stem cells as a model for cardiac differentiation induced by ascorbic acid used and the pattern of expression of PEP at certain stages of differentiation were analyzed by Real-Time PCR technique. The results show a dramatic increase in PEP gene expression in the adult cardiomyocytes.

Shahin Asadi,student of Molecular Genetics, Studied Molecular Biology at Tabriz Islamic Azad University Sciences.Bachelor of Moleculer and Cellular Biology-Genetics,Master of Moleculer Biology and Genetics Director of research, nuclear researcher of the National Center for Genetic Engineering and Biotechnology in Iran.