Molecular Dynamics Simulations of the Neu Transmembrane Domain : Physical Characterization of Native and Mutated Neu in a Membrane Environment

Language: English

Published by VDM Verlag Dr. Müller, 2009

3639127625 / 9783639127621

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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nach der Bestellung gedruckt Neuware - Printed after ordering - Neu is a membrane-bound protein whose structureincludes a single helix which spans the width of acellular membrane. It is a growth factor receptorwhich dimerizes (forms pairs) when signaling cellgrowth and proliferation. Key mutations at a specificlocation in the transmembrane domain (TMD) of the neuprotein have been demonstrated to result in permanentdimerization of mutated pairs, and are simultaneouslyassociated with the formation of cancerous tumors.The physical effects of these key point mutationsthat lead to such permanent dimerization are notknown. Atomistic molecular dynamics (MD) simulations,whereby Newton's equations of motion are numericallysolved for the atoms in the neu TMD and itssurrounding membrane environment, provide furtherphysical insight into this important problem. Thisbook reviews the MD simulation method as well asprevious work characterizing the neu protein; thebook further examines the results of detailed MDsimulations of native and mutant neu TMDs in hydratedmembrane environments. The reader should have somebasic background in biophysical chemistry, Newtoniandynamics, and statistical mechanics.…

Seller Inventory # 9783639127621

Title
Molecular Dynamics Simulations of the Neu Transmembrane Domain : Physical Characterization of Native and Mutated Neu in a Membrane Environment
Author
Bryan van der Ende
Publisher
VDM Verlag Dr. Müller
Publication year
2009
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3639127625
ISBN 13
9783639127621
Item weight
308 grams
Dimensions
22.00x15.00x1.10 cm

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