Molecular and Histopathological Changes in Mouse Intestinal Tissue After Proton Exposure

Purgason, Ashley; Wu, Honglu

ISBN 10: 1289124639 / ISBN 13: 9781289124632

Published by Bibliogov, 2013

About this Item

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Bibliographic Details

• Title: Molecular and Histopathological Changes in Mouse Intestinal Tissue After Proton Exposure
• Publisher: Bibliogov
• Publication Date: 2013
• Language: English
• ISBN 10: 1289124639
• ISBN 13: 9781289124632
• Binding: Soft cover
• Condition: As New

About this title

Synopsis

Whole body exposure to protons in mice causes significant apoptosis in the crypts of the small intestine. Increasing numbers of crypts contained more apoptotic lesions as the dose of exposure increased. 16 genes associated with apoptotic pathways were shown to have significantly altered expression as compared to control samples for at least one of the doses of proton exposure 1 gene, Trp53inp1, was significantly up-regulated across all three doses. Those animals exposed to 0.1 Gy of proton irradiation showed greater amounts of significant alterations in gene expression as compared to 1 Gy and 2 Gy exposures. The differences in gene expression changes of low and high dose proton irradiated mice may offer insight into the molecular mechanisms of the possible high sensitivity at low proton doses. RAIDD (CRADD) may be responsible for the hypersensitivity observed in the duodenum of mice exposed to low doses of protons. Caspase-1 may also play a role in the hypersensitivity seen following proton irradiation at a dose of 0.1 Gy. FOXO3A may be involved in the down-regulation of GILZ observed at high doses of proton exposure.