Mouse Brain Development (Results and Problems in Cell Differentiation)

Andre M. Goffinet; Pasko Rakic

ISBN 10: 3540666648 / ISBN 13: 9783540666646

Published by Springer, 2000

About this Item

Hardcover, xiv + 339 pages, NOT ex-library. Gently used with light wear. Interior is clean with unmarked text, free of inscriptions and stamps, firmly bound. Issued without a dust jacket.

Seller Inventory # 007910

Bibliographic Details

• Title: Mouse Brain Development (Results and Problems in Cell Differentiation)
• Publisher: Springer
• Publication Date: 2000
• Language: English
• ISBN 10: 3540666648
• ISBN 13: 9783540666646
• Binding: Hardcover
• Condition: Good

About this title

Synopsis

Our understanding of the molecular mechanisms involved in mammalian brain development remains limited. However, the last few years have wit­ nessed a quantum leap in our knowledge, due to technological improve­ ments, particularly in molecular genetics. Despite this progress, the available body of data remains mostly phenomenological and reveals very little about the grammar that organizes the molecular dictionary to articulate a pheno­ type. Nevertheless, the recent progress in genetics will allow us to contem­ plate, for the first time, the integration of observation into a coherent view of brain development. Clearly, this may be a major challenge for the next century, and arguably is the most important task of contemporary develop­ mental biology. The purpose of the present book is to provide an overview that syn­ thesizes up-to-date information on selected aspects of mouse brain devel­ opment. Given the format, it was not possible to cover all aspects of brain development, and many important subjects are missing. The selected themes are, to a certain extent, subjective and reflect the interests of the contributing authors. Examples of major themes that are not covered are peripheral nervous system development, including myelination, the development of the hippocampus and several other CNS structures, as well as the developmental function of some important morphoregulatory molecules.

From the Back Cover

With the enormous development of human and mouse genomics and the availability of a variety of transgenic techniques, the mouse has become the most widely used animal for basic studies of brain development and as a model for human developmental disorders. The topics are addressed using a diversity of techniques, from genetic, biochemical and cell biological to morphological and functional. The conceptual approaches also provide a framework for studies of other problems and point the way towards future research.