Multinuclear Pyrazolate-Based Copper Complexes Inspired by the CuZ-Site of N2O-Reductases

Vera Konstanzer

ISBN 10: 3869559780 / ISBN 13: 9783869559780

Published by Cuvillier Dez 2011, 2011

About this Item

This item is printed on demand - it takes 3-4 days longer - Neuware -Enzymes with multicopper active sites play important roles in many biological processes. Recently a novel multinuclear copper site was discovered in N2O-Reductase and its exact structure and mechanism has been much discussed since then. The so called CuZ center contains a unique tetranuclear Cu4S2-Cluster, which is coordinated by seven histidine residues. Until now no synthetic model complex could be isolated that emulates the Cu4S2 core of the active site.In this thesis a new strategy towards such model systems is introduced. To mimic the nitrogen-rich environment of the copper ions, pyrazolate-based ligand scaffolds with chelating N-donor side arms are employed. The resulting binuclear metal complexes were isolated and fully characterized. Additionally the reactivity of these binuclear building blocks towards various sulfur-containing coligands and sulfur-transfer reagents was investigated. 206 pp. Englisch.

Seller Inventory # 9783869559780

Bibliographic Details

• Title: Multinuclear Pyrazolate-Based Copper Complexes Inspired by the CuZ-Site of N2O-Reductases
• Publisher: Cuvillier Dez 2011
• Publication Date: 2011
• Language: English
• ISBN 10: 3869559780
• ISBN 13: 9783869559780
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 210W x 148H x 11D millimeters 210 millimeters width by 148 millimeters height by 11 millimeters depth
• Weight: 274 grams

About this title

Synopsis

Enzymes with multicopper active sites play important roles in many biological processes. Recently a novel multinuclear copper site was discovered in N2O-Reductase and its exact structure and mechanism has been much discussed since then. The so called CuZ center contains a unique tetranuclear Cu4S2-Cluster, which is coordinated by seven histidine residues. Until now no synthetic model complex could be isolated that emulates the Cu4S2 core of the active site. In this thesis a new strategy towards such model systems is introduced. To mimic the nitrogen-rich environment of the copper ions, pyrazolate-based ligand scaffolds with chelating N-donor side arms are employed. The resulting binuclear metal complexes were isolated and fully characterized. Additionally the reactivity of these binuclear building blocks towards various sulfur-containing coligands and sulfur-transfer reagents was investigated.