Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This volume brings together a wide range of reviews on different aspects of our knowledge of drug-resistance mechanisms. It includes coverage of topics such as: DNA repair, topoisomerases and cell cycle control. Editor(s): Clynes, Manfred. Num Pages: 344 pages, biography. BIC Classification: MBGR; MJCL2. Category: (P) Professional & Vocational. Dimension: 254 x 178 x 21. Weight in Grams: 960. . 1999. Reprinted from cytechnology, 27:1-3, 1998. Hardback. . . . .

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Bibliographic Details

Title: Multiple Drug Resistance in Cancer
Publisher: Kluwer Academic Publishers
Publication Date: 1999
Language: English
ISBN 10: 0792352726
ISBN 13: 9780792352723
Binding: Hardcover
Condition: New

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Synopsis

Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.

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