Multiple Drug Resistance in Cancer 2: Molecular, Cellular and Clinical Aspects

Clynes, Martin (Edited by)

ISBN 10: 9048151082 / ISBN 13: 9789048151080

Published by Springer, 2010

About this Item

300 pages. 10.50x8.00x0.84 inches. In Stock.

Seller Inventory # zk9048151082

Bibliographic Details

• Title: Multiple Drug Resistance in Cancer 2: Molecular, Cellular and Clinical Aspects
• Publisher: Springer
• Publication Date: 2010
• Language: English
• ISBN 10: 9048151082
• ISBN 13: 9789048151080
• Binding: Paperback
• Condition: Brand New

About this title

Synopsis

Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.