Multiple Drug Resistance in Cancer 2 : Molecular, Cellular and Clinical Aspects
Clynes, Martin (EDT)
ISBN 10: 0792352726 ISBN 13: 9780792352723
Published by Springer, 1999
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Synopsis:
Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.
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Bibliographic Details
Title: Multiple Drug Resistance in Cancer 2 : ...
Publisher: Springer
Publication Date: 1999
Binding: Hardcover
Condition: New