NF-kB: A Network Hub Controlling Immunity, Inflammation, and Cancer (Cold Spring Harbor Perspectives in Biology)

Karin, Michael and M. Staudt Louis:

ISBN 10: 0879699027 / ISBN 13: 9780879699024

Published by Cold Spring Harbor Laboratory Press,U.S., 2010

About this Item

271 Seiten; 9780879699024.2 Gewicht in Gramm: 1.

Seller Inventory # 1193113

Bibliographic Details

• Title: NF-kB: A Network Hub Controlling Immunity, Inflammation, and Cancer (Cold Spring Harbor Perspectives in Biology)
• Publisher: Cold Spring Harbor Laboratory Press,U.S.
• Publication Date: 2010
• Language: English
• ISBN 10: 0879699027
• ISBN 13: 9780879699024
• Binding: hardcover
• Condition: Sehr gut
• Weight: 1 gram
• Seller catalogs:
  • Varia

About this title

Synopsis

NF-kB is a critical signaling molecule in the immune system that regulates cell survival and cell death, lymphocyte responses, and inflammation. Acting as a transcription factor that can receive several inputs, it coordinates distinct gene expression programs in response to a wide variety of stimuli. Written and edited by experts in the field, this volume includes contributions covering the structure of NF-kB, its DNA-binding activity and specificity, the role of the inhibitor I-?B, and canonical and alternative mechanisms of NF-kB activation. The contributors examine the physiological role of NF-kB in immune cells, as well as its functions in other tissues, such as the nervous system. They also discuss work indicating that NF-kB represents a critical link between inflammation and cancer. Including clinical perspectives on the use of NF-kB inhibitors in cancer therapy and a historical introduction by David Baltimore, in whose lab NF-kB was discovered, this volume is a vital reference for cell and molecular biologists, immunologists, and pathologists interested in regulation of cell function.

About the Author

Edited by Michael Karin, University of California, San Diego, and Louis M. Staudt, National Cancer Institute