Nanotoxicity From In Vivo and In Vitro Models to Health Risks

Nanomaterials - substances smaller than 100 nanometers in size - have been added in recent years to an increasing numbers of consumer products used in day-to-day life; in food packaging, medical devices, pharmaceuticals, cosmetics, odor-resistant textiles and household appliances. The extensive application of nanomaterials in a wide range of products for human use poses a potential for toxicity risk to human health and the environment. Such adverse effects of nanomaterials on human health have triggered the development of a new scientific discipline known as “nanotoxicity” – the study of the toxicity of nanomaterials.

Nanotoxicity: From in vivo and in vitro Models to Health Risks provides up-to-date state-of-the-art information presented by recognized experts in this emerging new field in toxicology. It discusses the safety evaluation of nanomaterials in foods, drugs, medical devices, cosmetics and other regulated products and its use in risk analysis for potential regulatory use. Topics covered include:

• biomarkers for nanotoxicity assessment
• nanotoxicity assessment by gene expression analysis
• in vivo and in vitro models for nanotoxicity testing
• mechanisms of nanotoxicity
• pharmakokinetics of nanomaterials
• nanotoxicity of foods including food processing, food packaging and food safety
• nanotoxicity of drugs including drug development and drug delivery
• nanotoxicity of cosmetics and consumer products
• health and environmental impact of nanotoxicity
• safety evaluation of nanomaterials
• regulatory impact of nanomaterials

Nanotoxicity: From in vivo and in vitro Models to Health Risks is a valuable authoritative source of information for readers from a wide range of disciplines such as toxicology, pharmacology, drug toxicity and food and environmental sciences. The book will be useful to the research community in academia, industry, hospitals and government, as well as to government regulators and risk assessors of foods, drugs and environmental and agricultural products.

Dr. Saura C. Sahu, Research Chemist, Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration.
Dr. Sahu is the US Editor for the Journal of Applied Toxicology and the editor of Hepatotoxicity (Wiley, Dec 2007), and Toxicogenomics (Wiley, Oct 2008).

Professor Daniel A. Casciano, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Professor Casciano was former director of the US Food and Drug Administration's National Center for Toxicological Research in Jefferson, Arkansas, USA.