Natural Compounds Modulate an Arsenal of ncRNAs in Breast Cancer

Language: English

Published by LAP LAMBERT Academic Publishing Nov 2020, 2020

6203193585 / 9786203193589

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Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germanybuchversandmimpf2000

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Softcover

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This item is printed on demand - Print on Demand Titel. Neuware -Triple Negative Breast Cancer (TNBC) is believed to be an immunogenic tumor, therefore; immunotherapy has arisen to be a promising approach for TNBC treatment. Immune escape can be caused by the inactivation of natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). NKs and CTLs express an array of activating receptors on their surface that bind to unique activating ligands exclusively present on cancer cells such as MICA, MICB and CD155. Unfortunately, the expression of these immune ligands is decreased by malignant cells through their shedding down. Interestingly, non-coding RNAs (ncRNAs) can regulate the surface expression of the activating ligands on cancer cells directly and indirectly. Some plant products were known as modulators of ncRNAs expression in a variety of cancers. Vitexin, is a flavone C-glycoside which impairs the viability and induces the apoptosis in some cancer cells. Our ultimate goal was to investigate the impact of ncRNAs in up-streaming MICA, MICB and CD155 expression levels in TNBC cells. Moreover; investigating the effect of the 3'-O-acetylvitexin derivative which is a more potent form of Vitexin on ncRNAs and the activating ligands expression.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 144 pp. Englisch.…

Seller Inventory # 9786203193589

Title
Natural Compounds Modulate an Arsenal of ncRNAs in Breast Cancer
Author
Aisha ElKhouly
Publisher
LAP LAMBERT Academic Publishing Nov 2020
Publication year
2020
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
6203193585
ISBN 13
9786203193589
Item weight
233 grams
Dimensions
220x150x10 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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