Building on the foundation of the first edition, this thoroughly updated volume reflects the rapid advancements and expanding clinical relevance of navigated transcranial magnetic stimulation (nTMS) in neurosurgery. Once primarily a tool for preoperative mapping of cortical motor and language functions, nTMS is now increasingly recognized as a versatile instrument for individualized neurosurgical planning, risk stratification, and targeted neuromodulation.
This second edition presents these principles of perioperative neurophysiology with new insights into the integration of nTMS with cutting-edge technologies such as advanced tractography and connectomic analyses offering a more nuanced view of brain networks and their role in both mapping and therapeutic contexts. Emerging applications—such as closed-loop stimulation and post-spinal cord injury rehabilitation—are covered in depth, reflecting the field’s shift toward personalized neuromodulatory interventions.
As in the first edition, the book serves both as a practical guide and a reference: neurosurgeons and neuroscientists new to nTMS will find essential protocols and implementation strategies, while experienced users will benefit from expert analysis of the latest techniques and clinical applications. Each chapter is authored by leading figures in the field, selected for their pioneering contributions and international expertise.
With a spirit of collaboration and innovation at its core, this book captures the momentum and promise of nTMS in modern neurosurgery—moving from isolated functional regions to a network-based approach that is transforming patient care.
Prof. Thomas Picht (Charité – Universitätsmedizin Berlin) and Prof. Sandro Krieg (Heidelberg University Hospital) have been at the forefront of advancing navigated transcranial magnetic stimulation (nTMS) in neurosurgery for over a decade. As internationally recognized experts in eloquent brain tumor surgery, they have relentlessly driven innovation in non-invasive brain mapping, helping to refine surgical strategies and improve patient outcomes. Their collaboration is marked by a strong commitment to international exchange, reflected in numerous joint publications with global partners and their long-standing role as co-hosts of the annual International Symposium on nTMS in Neurosurgery. Together, they have shaped the clinical translation of nTMS from cutting-edge research to a widely adopted tool in neurosurgical planning. Their combined efforts continue to push the boundaries of technology-driven, patient-centered neurosurgical care.
