Neonatal Mucosal Colonisation

Ülle Parm

ISBN 10: 384335832X / ISBN 13: 9783843358323

Published by LAP LAMBERT Academic Publishing Mai 2012, 2012

About this Item

This item is printed on demand - it takes 3-4 days longer - Neuware -The prospective open label two centre cluster randomised study was conducted in two neonatal intensive care units (NICU) in Estonia. We compared how antibiotics commonly used for empiric therapy of early onset sepsis influence the development of infants mucosal microbiota; identified other risk factors influencing the colonisation process; identified the relatedness of mucosal and blood isolates; defined the value of twice a week collected surveillance cultures in predicting late onset sepsis (LOS).Results showed that risk factors influencing nasopharyngeal and rectal colonisation are similar and species-specific and are closely inter-related making extrapolations from one site to the other feasible. The impact of ampicillin compared with penicillin on mucosal colonisation with Gram-negative ampicillin-resistant strains may have been over-estimated. The frequent opportunistic colonisers were also frequent causative agents of LOS. However, the sensitivity and specificity of mucosal surveillance samples in predicting invasive disease is suboptimal. So, routine and non-targeted surveillance cultures are not efficient in predicting LOS in NICU. 120 pp. Englisch.

Seller Inventory # 9783843358323

Bibliographic Details

• Title: Neonatal Mucosal Colonisation
• Publisher: LAP LAMBERT Academic Publishing Mai 2012
• Publication Date: 2012
• Language: English
• ISBN 10: 384335832X
• ISBN 13: 9783843358323
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 8D millimeters 220 millimeters width by 150 millimeters height by 8 millimeters depth
• Weight: 197 grams

About this title

Synopsis

The prospective open label two centre cluster randomised study was conducted in two neonatal intensive care units (NICU) in Estonia. We compared how antibiotics commonly used for empiric therapy of early onset sepsis influence the development of infants mucosal microbiota; identified other risk factors influencing the colonisation process; identified the relatedness of mucosal and blood isolates; defined the value of twice a week collected surveillance cultures in predicting late onset sepsis (LOS).Results showed that risk factors influencing nasopharyngeal and rectal colonisation are similar and species-specific and are closely inter-related making extrapolations from one site to the other feasible. The impact of ampicillin compared with penicillin on mucosal colonisation with Gram-negative ampicillin-resistant strains may have been over-estimated. The frequent opportunistic colonisers were also frequent causative agents of LOS. However, the sensitivity and specificity of mucosal surveillance samples in predicting invasive disease is suboptimal. So, routine and non-targeted surveillance cultures are not efficient in predicting LOS in NICU.

About the Author

University of Tartu, Tartu Health Care College PhD in medicine