Neuro Protective Effect of N6- Isopentanyl Adenosine

Alzheimer's disease (AD), the most prevalent form of dementia, is a progressive neurodegenerative disorder that affects millions, particularly in the aging population. Characterized by senile plaques, amyloid-beta (Aβ) deposits, neurofibrillary tangles, and selective neuronal loss, AD leads to a gradual decline in cognitive function, memory, and daily functioning. While current treatments primarily target symptomatic relief by modulating neurotransmitter levels, they do little to halt the disease's progression.N6-Isopentyladenosine (iPA), a naturally occurring purine derivative, holds promise as a novel therapeutic approach in neurodegenerative diseases like Alzheimer's. With its remarkable anti-inflammatory, antioxidant, and anti-apoptotic properties, iPA has been shown to modulate key signaling pathways that promote neuronal survival and plasticity. Preclinical studies have demonstrated its potential to reduce inflammation, attenuate neuronal damage, and improve cognitive function in animal models, offering new hope for AD patients.