Neuroactivation and Neuroimaging with SPET

Neuroactivation and Neuroimaging with SPET — George et al. (1991, 1st Edition) Neuroactivation and Neuroimaging with SPET presents one of the early comprehensive treatments of functional brain imaging using single photon emission tomography (SPET/SPECT). Written by Mark S. George, Howard A. Ring, Durval C. Costa, Peter J. Ell, Kypros Kouris and Peter H. Jarritt, the book explains how radiopharmaceutical tracers and tomographic techniques can be used to visualize regional cerebral blood flow and brain function in both normal subjects and patients with neurological or psychiatric disorders. The authors lay out the principles of emission tomography and SPET instrumentation, then move into detailed clinical applications. Separate chapters discuss protocols for neuroactivation studies, in which cognitive, sensory or motor tasks are used to “activate” specific brain regions during imaging. Case material and imaging examples cover dementia syndromes, cerebrovascular disease, movement disorders, epilepsy, schizophrenia, obsessive–compulsive disorder and other conditions. The text correlates SPET findings with anatomical information from CT and MRI, giving readers a bridge between structural and functional imaging. Book Details Title: Neuroactivation and Neuroimaging with SPET Authors: Mark S. George, Howard A. Ring, Durval C. Costa, Peter J. Ell, Kypros Kouris, Peter H. Jarritt Edition: First Edition ISBN-10: 354019701X Subject Area: Nuclear Medicine, Functional Neuroimaging, Neurology, Psychiatry Contents & Topics Fundamentals of emission tomography and SPET physics, including detectors, collimation and image reconstruction. Radiopharmaceutical ligands and tracers used to measure regional cerebral blood flow and receptor binding. High-resolution SPET imaging protocols and technical considerations for brain studies. Clinical applications in dementia, cerebrovascular disease, movement disorders, epilepsy, psychiatric illness and other brain conditions. Design and interpretation of neuroactivation studies using task-based paradigms in normal subjects and patient groups. Discussion of models of brain processing, localization of function and the relationship between structure and function. Appendices with practical guidance on activation tasks, protocol design and performing SPET neuroactivation studies. Integrates physics, radiopharmacy, instrumentation and clinical neuroimaging into a single reference. Provides detailed imaging examples and case histories illustrating patterns of cerebral blood flow in various diseases. Explains how to plan, carry out and analyze SPET-based neuroactivation experiments. Offers an important historical perspective on the development of functional brain imaging and its clinical applications. Useful for nuclear medicine physicians, neurologists, psychiatrists, radiologists and researchers working with SPET/SPECT. A focused and technically rich monograph, Neuroactivation and Neuroimaging with SPET remains a valuable reference for understanding early functional SPET techniques and their application to the study of brain function in health and disease. ).…