Neuronal Network Dynamics in 2D and 3D in vitro Neuroengineered Systems

Monica Frega

ISBN 10: 3319302361 / ISBN 13: 9783319302362

Published by Springer, Springer, 2016

About this Item

Druck auf Anfrage Neuware - Printed after ordering - The bookpresents a new, powerful model of neuronal networks, consisting of athree-dimensional neuronal culture in which 3D neuronal networks are coupled tomicro-electrode-arrays (MEAs). It discusses the main advantages of thethree-dimensional system compared to its two-dimensional counterpart, and showsthat the network dynamics, recorded during both spontaneous and stimulatedactivity, differs between the two models, with the 3D system being better ableto emulate the in vivo behaviour of neural networks. The book offers anextensive analysis of the system, from the theoretical background, to itsdesign and applications inneuro-pharmacological studies. Moreover, itincludes a concise yet comprehensive introduction to both 2D and 3D neuronalnetworks coupled to MEAs, and discusses the advantages, limitations andchallenges of their applications as cellular and tissue-like in vitro experimental model systems.

Seller Inventory # 9783319302362

Bibliographic Details

• Title: Neuronal Network Dynamics in 2D and 3D in vitro Neuroengineered Systems
• Publisher: Springer, Springer
• Publication Date: 2016
• Language: English
• ISBN 10: 3319302361
• ISBN 13: 9783319302362
• Binding: Buch
• Condition: Neu
• Dimensions: 241W x 160H x 15D millimeters 241 millimeters width by 160 millimeters height by 15 millimeters depth
• Weight: 418 grams

About this title

Synopsis

The book presents a new, powerful model of neuronal networks, consisting of a three-dimensional neuronal culture in which 3D neuronal networks are coupled to micro-electrode-arrays (MEAs). It discusses the main advantages of the three-dimensional system compared to its two-dimensional counterpart, and shows that the network dynamics, recorded during both spontaneous and stimulated activity, differs between the two models, with the 3D system being better able to emulate the in vivo behaviour of neural networks. The book offers an extensive analysis of the system, from the theoretical background, to its design and applications in neuro-pharmacological studies. Moreover, it includes a concise yet comprehensive introduction to both 2D and 3D neuronal networks coupled to MEAs, and discusses the advantages, limitations and challenges of their applications as cellular and tissue-like in vitro experimental model systems.