Neutrophils are no longer seen as simple, short-lived defenders. Recent research shows they actively shape cancer progression by influencing immunity, inflammation, and the tumor environment. In oral cancer, factors like aging, smoking, and oral inflammation can disturb neutrophil function, creating conditions that support immune escape and malignant change.This book highlights the emerging evidence linking neutrophils to prognosis in oral cancer and their potential as cost-effective biomarkers. By understanding how these cells contribute to disease behavior, new opportunities for targeted therapies and personalized treatment approaches continue to grow.

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