New Developments in the Pathogenesis of Rheumatoid Arthritis

Language: English

Published by Intechopen Feb 2017, 2017

9535129694 / 9789535129691

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This item is printed on demand - Print on Demand Titel. Neuware -The pathogenesis of rheumatoid arthritis (RA) is incompletely understood. HLA class II alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (ACPAs), along with the effectiveness of biological treatments targeting cytokines, such as TNF- , IL-6, and also T cells and B cells, reinforced the pathogenetic role of the respective factors. ACPAs, induced by cigarette smoking and periodontitis in individuals with HLA-DRB1 shared epitope, appear to be autoantigens that initiate the inflammatory immune response in RA. MicroRNAs, part of epigenetic mechanisms, which also include DNA methylation, and histone modification, as well as microbiota, the composition of microbes in body cavities, also appear to influence arthritis and are discussed in this book.Books on Demand GmbH, Überseering 33, 22297 Hamburg 164 pp. Englisch.

Seller Inventory # 9789535129691

Title
New Developments in the Pathogenesis of Rheumatoid Arthritis
Author
Lazaros Sakkas
Publisher
Intechopen Feb 2017
Publication year
2017
Condition
Neu
Binding
Buch
Language
English
ISBN 10
9535129694
ISBN 13
9789535129691
Item weight
575 grams
Dimensions
266x185x16 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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