A New Model for Analyzing Antimicrobial Peptides With Biomedical Applications (Nato: Life and Behavioural Sciences, 343)

NATO Advanced Research Workshop on a New Model for Analyzing Antimicrobial Pepti, Edwin L. Cooper, Alain Beschin et Martin Bilej

ISBN 10: 1586032372 / ISBN 13: 9781586032371

Published by Ios Pr Inc, 2002

About this Item

Ancien livre de bibliothèque avec équipements. Couverture différente. Edition 2002. Ammareal reverse jusqu'à 15% du prix net de cet article à des organisations caritatives. ENGLISH DESCRIPTION Book Condition: Used, Very good. Former library book. Different cover. Edition 2002. Ammareal gives back up to 15% of this item's net price to charity organizations.

Seller Inventory # G-082-424

Bibliographic Details

• Title: A New Model for Analyzing Antimicrobial Peptides With Biomedical Applications (Nato: Life and Behavioural Sciences, 343)
• Publisher: Ios Pr Inc
• Publication Date: 2002
• Language: English
• ISBN 10: 1586032372
• ISBN 13: 9781586032371
• Binding: Hardcover
• Condition: Très bon

About this title

Synopsis

Using the earthworm as their window into comparative immunology, the authors of these 18 papers sought to shed new light on the potential biomedical applications and characterization of annelid worm antimicrobial lytic factors. Presented by Cooper (Laboratory of Comparative Immunology, Philip Geffen School of Medicine, U. of California), Beschin (immunology, parasitology, and ultrastructure, Flemish Interuniversity Institute for Biotechnology, Belgium), and Bilej (immunology and gnotobiology, Academy of Sciences of the Czech Republic), the papers examine the mechanisms of lytic and antimicrobial activities, identify target molecules, explore long range potential applications of the molecules, and compare findings with data on similar molecules in other invertebrate species. Annotation ©2004 Book News, Inc., Portland, OR (booknews.com)

From the Back Cover

This book is aimed at two audiences. First, it will present evidence for the earthworm’s immune system. Second, the results strongly suggest that certain molecules of the earthworm’s immune system may be exploited as natural antibiotics—thus the biomedical applications. There are two advantages for using earthworms. First, they are an inexpensive, non-controversial invertebrate model. Second, in contrast to other invertebrates (e.g. Drosophila, C elegans) they are essential for maintaining the integrity of soil. Earthworms have a highly effective immune system since cancer cannot be induced in them nor does it seem to occur in natural populations. Cytotoxicity of cancer cells has been examined in relation to two earthworm leukocytes based upon: structure; cell differentiation antigens; function revealed by FACS and mAbs. These cells are SMALL (8-11 µm) electron dense (SC), positive for human cell adhesion molecules (CD11a, CD45RA, CD45RO, CDw49b, CD54, for ?2-microglobulin and for Thy-1; LARGE (12-15 µm) electron lucent cells (LC), negative for these same markers. Leukocytes synthesize and secrete lytic molecules (fetidins, CCF-1, lysenin, eiseniapore) participate in recognition of, binding to, killing and sequestration of cancer cells in vitro. Earthworm lytic levels are significantly higher than those of human NK cells. Earthworms possess a highly evolved, unique and efficient immune system that has facilitated long-term survival.