Next Generation Smart Nano-Bio-Devices

This book addresses challenges for the development of a point-of-care-test platform. The book describes printed chip-based assay (Lab-on-a-Chip, Lab-on-a-PCB) for rapid, inexpensive biomarkers detection in real samples. The main challenges of point-of-care testing require implementing complex analytical methods into low-cost technologies. This is particularly true for countries with less developed healthcare infrastructure. Washing-free, Lab-on-Chip, and Lab-on-PCB techniques are very simple and innovative for point-of-care device development. The redox cycling technology detects several interesting targets at the same time on a printed chip. The proposed areas are inherently cross-disciplinary, combining expertise in biosensing, electrochemistry, electronics and electrical engineering, health care, and manufacturing. This book focuses on recent advances and different research issues in the nanobiotechnology-enabled biosensor technology and also seeks out theoretical, methodological, well-established, and validated empirical work dealing with these different topics.

Dr. Gorachand Dutta is Assistant Professor at School of Medical Science and Technology, IIT Kharagpur. He received M.Sc. degree in Chemistry from Indian Institute of Technology, Guwahati, India. His research interests include the design and characterization of portable biosensors, biodevices, and sensor interfaces for miniaturized systems and biomedical applications for point-of-care testing. He received his Ph.D. in Biosensor and Electrochemistry from Pusan National University, South Korea, where he developed different class of electrochemical sensors and studied the electrochemical properties of gold, platinum, and palladium-based metal electrodes. He completed his postdoctoral fellowships in the Department of Mechanical Engineering, Michigan State University, USA, Department of Chemistry, Pusan National University, South Korea, and Centre for Biosensors, Bioelectronics and Biodevices at University of Bath, UK. During his research tenure in USA and South Korea, Dr. Dutta inventedan enzyme-free, disposable miniaturized immunosensor chip using micropatterned electrode and wash-free method for the development of mobile phone-based platforms for fast and simple point-of-care testing of infectious and metabolic disease biomarkers. He has expertise on label-free multichannel electrochemical biosensors, electronically addressable biosensor arrays, aptamer- and DNA-based sensors, and surface bio-functionalization.