Nisin Based Lantibiotic Engineering: A Novel Approach On Biopreservation

Mohanasrinivasan, V.; Devi, C.Subathra; E., Suganthi V. Selvarajan; Mohanasrinivasan, V.; Devi, C.Subathra; E., Suganthi V. Selvarajan

ISBN 10: 3659254738 / ISBN 13: 9783659254734

Published by Lap Lambert Academic Publishing, 2012

About this Item

80 pages. 8.66x5.91x0.19 inches. In Stock.

Seller Inventory # 3659254738

Bibliographic Details

• Title: Nisin Based Lantibiotic Engineering: A Novel Approach On Biopreservation
• Publisher: Lap Lambert Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3659254738
• ISBN 13: 9783659254734
• Binding: Paperback
• Condition: Brand New
• Weight: 0.17 kilograms

About this title

Synopsis

Lantibiotics are ribosomally synthesized polycyclic peptide containing unusual amino acids, which have binding specificity for bacterial cells, targeting the bacterial cell wall component lipid II to form pores and there by lyses the cell. Nisin is the one of the most studied commonly used lantibiotics. Nisin inhibit the growth of bacteria by inhibiting cell wall synthesis via binding to Lipid II. Nisin have thio esters five ring system. But first three are actively involved in antimicrobial activity. These are binding to pyrophosphate moiety of lipid II. This mode of action is the rationale for design of small nisin derived peptide to obtain novel potential lantibiotics. As conformational constraints the Thioether Bridge was mimicked by alkanes or alkenes by ring closing metathesis.

About the Author

Dr.V.Mohanasrinivasan and Dr.C.Subathra Devi are currently working as Assistant Professor senior at VIT University, Vellore, Tamil Nadu, India. Both of them are expertise in industrial enzymes and proteins.Currently their team is working especially on Bacteriocins,lactase for lactose free product development and clot buster enzymes.