Nitrates Updated : Current Use in Angina, Ischemia, Infarction and Failure

Language: English

Published by Springer Us Jan 1997, 1997

0792334663 / 9780792334668

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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Neuware - Nitrates remain among the most commonly used therapeutic agents in cardiology. That they can re lieve pain in angina pectoris has been known at least since 1867, when Lauder Brunton described their clinical use. Now, almost 130 years later, we are constantly learning more about their optimal use in anginal syndromes. For example, there is no doubt that nitrate tolerance occurs, but equally no doubt that certain drug dosages help to attenuate such toler ance. Thus, our understanding of nitrate tolerance has been taken further by the advent of new nitrate preparations and by studies at a basic science level. The current intense interest in nitrates has been rekindled by the growing emphasis on the role of the endothelium in the production of nitric oxide, a basic cardiovascular regulator. If nitric oxide is vasodilator and protects the vascular endothelium, then nitrates should also have similar properties. Hence this book starts off with the role of the endothelium and ni trates in vasodilation. Next, the mechanisms of ac tion of nitrates are considered with emphasis on the role of cyclic GMP. The chief limitation to the use of nitrates lies in nitrate tolerance. After carefully looking at all the evidence, the authors of the third chapter conclude that the mechanism is likely to be multifactorial. The mechanism responsible for the tolerance still remains unknown. In vitro tolerance may be due to enhanced production of vascular superoxide [1].…

Seller Inventory # 9780792334668

Title
Nitrates Updated : Current Use in Angina, Ischemia, Infarction and Failure
Author
Lionel H Opie
Publisher
Springer Us Jan 1997
Publication year
1997
Condition
Neu
Binding
Buch
Language
English
ISBN 10
0792334663
ISBN 13
9780792334668
Item weight
508 grams
Dimensions
234x156x14 mm

AHA-BUCH GmbH

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