Nmr Spectroscopy in Drug Development and Analysis

Diehl, Bernd

ISBN 10: 3527300929 / ISBN 13: 9783527300921

Published by Wiley-Vch, 1999

About this Item

This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,800grams, ISBN:9783527300921.

Seller Inventory # 2286124

Bibliographic Details

• Title: Nmr Spectroscopy in Drug Development and Analysis
• Publisher: Wiley-Vch
• Publication Date: 1999
• Language: English
• ISBN 10: 3527300929
• ISBN 13: 9783527300921
• Binding: Hardcover
• Condition: Good
• Weight: 800 grams
• Seller catalogs:
  • Medicine

About this title

Synopsis

Since the development of the NMR spectrometer in the 1950s, NMR spectra have been widely used for the elucidation of the 2D structure of newly synthesized and natural compounds. In the 1980s, the high-resolution NMR spectrometer (> 300 Mhz) and 2D experiments were introduced, which opens up the possibility to determine the 3D structure of large molecules, especially biomolecules. However, NMR spectroscopy has been rarely applied to drug analysis.
This book illustrates the power and versatility of NMR spectroscopy in the determination of impurities in and the content of drugs, the composition of polymer excipients, the characterization of isomeric drug mixtures, the complexity of drugs with small-size components or ions, and the behavior of drugs in acid and basic solution. In addition, NMR spectroscopy and especially the hyphenated technique with HPLC is shown to be a powerful tool to measure a drug and its metabolites in various body fluids. The solid state NMR technique can give information on the structure, especially the conformation of drugs and excipients in drug formulations. Recently, SAR by NMR, introduced by Fesik, impressively demonstrated the potential of NMR spectroscopy in drug development and in the characterization of the interaction between large molecules and ligands. The complexation between proteins, lipids and cyclodextrins with drugs is described. Finally, NMR imaging (MRI and MRS) can be used to characterize the liberation of drugs from a drug formulation. Furthermore, the distribution of substances in plants, in animals, in tissues and in humans can be visualized by imaging.
In short, this book covers all aspects of drug analysis.

About the Author

Ulrike Holzgrabe and Iwona Wawer are the authors of NMR Spectroscopy in Drug Development and Analysis, published by Wiley.