Nodular forms of goiter with autoimmune thyroiditis, thyroid adenoma: Polymorphic variants of genes BCL-2, CTLA-4, APO-1 / Fas in patients with thyroid pathology regarding its forms.

Abstract To analyze the frequency of polymorphic variants of genes BCL-2, CTLA-4, APO-1 / Fas in patients with thyroid pathology regarding its forms: nodular goiter with autoimmune thyroiditis and thyroid adenoma. Results: Mutation of BCL-2 and CTLA-4 genes in the homozygous state among resident’s adult population of Northern Bukovina occurs with a fre-quency 3,2-4,0%, no reliable difference between patients and healthy. Muta-tions of the gene APO-1 / Fas in the homozygous state are not observed. The nature of allelic distribution set: parity ratio between the main A and G minor alleles of the BCL-2 gene. A dominance of wild-allele mutation of the G-allele CTLA-4 gene 2.57 times among patients, and 3.54 times among healthy; and the prevalence of G-allele mutation of the A-allele gene Fas – 9.87 times in pa-tients and 7.33 times – in healthy. Conclusions: Pathology of the thyroid gland in general has unreliable chances to be inherited depending on the polymorphism of BCL-2, CTLA-4 and Fas genes in Bukovina (Western Ukraine).

In 2006 he defended his Ph.D. thesis "Complex treatment of nodular forms of goiter and prevention of postoperative complications". In 2016 he planned his doctoral dissertation on the theme "Autoimmune thyroiditis: pathogenic mechanisms of development, diagnostic, prognosis of course, surgical treatment".