The gut microbiome has emerged as a pivotal determinant of human health, shaping metabolic balance, immune responses, and vulnerability to disease. Growing scientific evidence reveals that natural products-ranging from dietary fibers and phytochemicals to bioactive microbial metabolites-offer powerful, non-invasive means to modulate gut microbial communities. Rather than disrupting microbial ecosystems, these compounds act through prebiotic, antimicrobial, and signaling pathways to foster resilience and host-microbe symbiosis.This book explores the molecular and ecological interactions between natural compounds and the gut microbiota, highlighting recent methodological advances and insights from both preclinical and clinical research. With a particular focus on plant-derived polyphenols, fibers, and microbiota-derived metabolites, it examines how natural products can be harnessed as precision tools for microbiome modulation. Addressing both therapeutic potential and translational challenges, this volume provides a forward-looking perspective on sustainable, nature-based strategies to support gut health and prevent disease.

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