Nonlinear Dendritic Processing in Rodent Somatosensory Cortex: Active Dendritic Properties of Layer 4 Spiny Stellate Neurons in the Barrel Cortex

Rapoport, Sophia

ISBN 10: 3659411876 / ISBN 13: 9783659411878

Published by LAP LAMBERT Academic Publishing, 2013

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Bibliographic Details

• Title: Nonlinear Dendritic Processing in Rodent Somatosensory Cortex: Active Dendritic Properties of Layer 4 Spiny Stellate Neurons in the Barrel Cortex
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2013
• Language: English
• ISBN 10: 3659411876
• ISBN 13: 9783659411878
• Binding: Paperback
• Condition: Like New
• Book Type: book

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Synopsis

Layer 4 neurons are the first cortical station that receives sensory information from the external world. The main recipients of this sensory input are the spiny stellate neurons. Thus, these neurons play a significant role in sensory information processing. However, the active mechanisms that are used by spiny stellate dendrites for shaping sensory responses are still unknown. This work investigates the active dendritic properties of layer 4 spiny stellate neurons by means of whole cell recordings, dendritic calcium imaging and glutamate uncaging in the thalamocortical slice preparation. The findings suggest that local and global dendritic spikes can amplify convergent thalamocortical and cortico-cortical inputs to layer 4 neurons and, thus, may have a substantial function in modulating the sensory signal transmitted by the thalamus.

About the Author

Dr. Sophia Rapoport is a senior scientist at the Spatial Perception and Memory Lab of the Technion Medical School, Haifa, Israel. She received the bachelor degree from Jerusalem College of Technology in 2005, and the M.S. and Ph.D. degrees from the Technion - Israel Institute of Technology, Haifa, in 2008 and 2012, respectively.