Novel Drug Delivery Systems For Gene-Targeted RNA Interference

Language: English

Published by LAP LAMBERT Academic Publishing Jan 2010, 2010

3838340914 / 9783838340913

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This item is printed on demand - Print on Demand Titel. Neuware -RNA interference refers to sequence-specific messenger RNA degradation initiated by introduction of short RNA duplexes. Since this event results in target-specific gene silencing, siRNAs are expected to serve as potential therapeutic agents to silence disease-causing genes. However, a substantial barrier to the therapeutic application is the delivery of siRNA duplexes into cells. Cyanocobalamin is one of the essential vitamins needed for the division of all cells. Cancer cells especially require abnormally high amounts of cobalamins due to rapid cell division. As a result, the cobalamin receptor density on the surface of the cell is over-expressed. Therefore, a 21 nucleotide long bcr-abl gene-specific siRNA was conjugated to cyanocobalamin, and its uptake, gene-silencing effect, and inhibition of cancer cell proliferation were investigated in K562 human chronic myelogenous leukemia cells. Results and findings discussed in this book indicate to open a door for the potential use of cobalamin as a novel carrier of siRNA for gene-targeted RNA interference.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 136 pp. Englisch.…

Seller Inventory # 9783838340913

Title
Novel Drug Delivery Systems For Gene-Targeted RNA Interference
Author
Randy Adachi
Publisher
LAP LAMBERT Academic Publishing Jan 2010
Publication year
2010
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3838340914
ISBN 13
9783838340913
Item weight
221 grams
Dimensions
220x150x9 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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