A Novel Pulsatile Drug Delivery System With Colon Specificity | A Complete Overview of Pulsatile Drug Delivery System

Mayur Doshi (u. a.)

ISBN 10: 3659299642 / ISBN 13: 9783659299643

Published by LAP Lambert Academic Publishing, 2012

About this Item

A Novel Pulsatile Drug Delivery System With Colon Specificity | A Complete Overview of Pulsatile Drug Delivery System | Mayur Doshi (u. a.) | Taschenbuch | Englisch | LAP Lambert Academic Publishing | EAN 9783659299643 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 106163479

Bibliographic Details

• Title: A Novel Pulsatile Drug Delivery System With Colon Specificity | A Complete Overview of Pulsatile Drug Delivery System
• Publisher: LAP Lambert Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3659299642
• ISBN 13: 9783659299643
• Binding: Taschenbuch
• Condition: Neu
• Seller catalogs:
  • Bücher

About this title

Synopsis

The aim of current study was to investigate the in-vitro performance of compress coated tablet of Atenolol. Administration of conventional tablet has been reported to exhibit fluctuation in the plasma drug level, resulting either in manifestation of side effect or reduction in drug concentration at the receptor site. Atenolol has strong absorption throughout GIT as well as in colon. But, it causes GI irritation problem. Hence it is always effective to have absorption of Atenolol at Colon site. A novel colon targeted tablet formulation was developed by press coating rapidly disintegrating tablet of Atenolol with HPMC K100M, guar gum and Eudragit S-100 as barrier layer. The device was enteric coated so that variability in gastric emptying time can be overcome and a colon specific release can be achieved. Different combinations of polymers were selected to achieve suitable lag time for the treatment of hypertension. In-vitro release study was carried out for prepared tablets, showed that the tablet coated with HPMC K100M, guar gum and Eudragit S-100 have limited drug release in stomach and small intestinal environment and released maximum amount of drug in the colonic environment.

About the Author

Mr. Mayur Doshi has completed Master’s degree in Pharmacy in Pharmaceutics subject from KLE's College of Pharmacy Nipani, Karnataka.He has completed his D.Pharm and B.Pharm from Pune University. Presently working as Jr. Research Scientist at Emcure Pharmaceuticals Pune. He is the author of several articles published in the reputed journals.