Nuclear and cytoplasmic control of the DNA damage checkpoint : A new way of looking at cell cycle control

Language: English

Published by LAP LAMBERT Academic Publishing, 2009

383830277X / 9783838302775

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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nach der Bestellung gedruckt Neuware - Printed after ordering - Cell cycle checkpoints are the means by which cells maintain their genomic integrity and resist factors that are potentially mutagenic. It is well known that there are different checkpoints for different stresses a cell could face, one of them being the DNA damage checkpoint. For long the activity of this checkpoint was thought to be limited to the nucleus. In this and other emerging studies it has now been established that the DNA damage checkpoint can regulate cell cycle arrest, nuclear positioning and movement by controlling cytoplasmic factors and events. This study establishes a novel regulatory mechanism of the DNA damage checkpoint involving vesicular transport system and cytoplasmic, non-proteosomal protein degradation. The study also focuses on the connection between the spindle assembly checkpoint (SAC) and the DNA damage checkpoint. To study this we generate an acentric chromosome with a single DNA double strand break on it. We find that budding yeast cells that have one chromosome with conditional GAL1-Cen centromere turned off cannot activate the SAC and both the sister chromatids of this chromosome get preferentially segregated to the mother cell.

Seller Inventory # 9783838302775

Title
Nuclear and cytoplasmic control of the DNA damage checkpoint : A new way of looking at cell cycle control
Author
Farokh Dotiwala
Publisher
LAP LAMBERT Academic Publishing
Publication year
2009
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
383830277X
ISBN 13
9783838302775
Item weight
298 grams
Dimensions
220x150x12 mm

AHA-BUCH GmbH

Einbeck, Germany

5-star seller

AbeBooks seller since August 14, 2006

Shipping rates from Germany to U.S.A.

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First itemUS$ 71.01US$ 82.56
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