Nutrition in the Control of Inflammation: Emerging Roles for the Microbiome and Epigenome

Nutrition in the Control of Inflammation: Emerging Roles for the Microbiome and Epigenome is a comprehensive guide that delves into the intricate relationship between diet and inflammation to regulate inflammatory diseases. Divided into five insightful sections, this book provides an introduction to the microbiome and epigenome in nutrition, exploring the impact of diet, lifestyle, and the microbiome on the development of inflammatory diseases. With a focus on nutrition and the epigenome in metabolic and cardiovascular diseases, the chapters tackle crucial topics such as histone modifications, DNA methylation, and non-coding RNAs in disease progression. Addressing health disparities in diet, epigenetics, and gut microbes, this book is a valuable resource for nutrition researchers, nutritionists, postgraduate students, and professionals in related fields. From the multifactorial microbial networks shaping aging to practical applications for diet and lifestyle improvements, this book offers practical insights for enhancing microbial and epigenetic health.

• Discusses the latest topics in the microbiome and nutritional epigenome surrounding the regulation of aging, development, metabolic disease, and heart disease
• Summarizes our current understanding of nutritional intervention in epigenetic reprogramming and microbial changes in the treatment and prevention of disease
• Provides practical applications for diet and lifestyle to reduce inflammation and improve overall health

Bradley S. Ferguson is an Associate Professor of Nutrition at the University of Nevada, Reno, Nevada. His lab adopts integrative, translational research approaches that encompass bioinformatics, in vitro cell culture, and in vivo animal models to elucidate dietary food components that act as epigenetic modifiers, as well as the role of dietary epigenetic modifiers on pathological cardiac signaling, gene expression, and remodeling. He also seeks to understand how sarcomere protein acetylation links metabolic disease (obesity and diabetes) to pathological cardiac remodeling and skeletal muscle dysfunction. Dr. Ferguson has published his findings across a wide range of peer-reviewed journals, including Scientific Reports, Journal of Animal Science, American Journal of Physiology, Cell Reports, PNAS, and the Journal of Molecular and Cellular Cardiology.

Steven Frese is an Assistant Professor of Nutrition at the University of Nevada, Reno, Nevada and holds an appointment as an Adjunct Assistant Professor at the Department of Food Science and Technology at the University of Nebraska, Lincoln. His research applies principles of microbial ecology and evolutionary biology to develop rational interventions to improve human health via the gut microbiome. This includes applying advanced techniques including bioinformatics, DNA/RNA sequencing, and mass spectrometry to determine strain- and ecosystem-level interactions both in vitro and in human clinical trials. His work has primarily focused on the gut microbiome in early life, and the role of diet and the microbiome in shaping infant health and development. Dr. Frese’s work has been published in a variety of broad interest peer-reviewed journals including Cell, Science Translational Medicine, Cell Host & Microbe, and PLoS Genetics, as well as audience-specific journals including Pediatric Research, Glycobiology, and Bioinformatics.