Omeprazole: A comparative in vitro dissolution study of different brands of omeprazole magnesium with reference product Losec 20

Kishor chakrabarty, Jayanta, Chandra Bachar, Sitesh, Kumar S

ISBN 10: 3659253952 / ISBN 13: 9783659253959

Published by LAP LAMBERT Academic Publishing, 2012

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Bibliographic Details

• Title: Omeprazole: A comparative in vitro dissolution study of different brands of omeprazole magnesium with reference product Losec 20
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3659253952
• ISBN 13: 9783659253959
• Binding: paperback
• Condition: Like New
• Book Type: book

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Synopsis

The main objective of present investigation was to study the dissolution pattern of most commercially available formulations of omeprazole in Bangladesh . Omeprazole magnesium is the most common antiulcerant in Bangladesh which are widely prescribed by the physicians for peptic ulcer & GERD. Ten national brands with reference brand of Omeprazole magnesium capsules were studied in stimulated gastric medium (pH 1.2) for first 2 hours and then in simulated intestinal medium (pH 6.8) for next 45 minutes using USP reference dissolution apparatus (Type 1 ) Among most of these locally manufactured Omeprazole brands showed compatible dissolution pattern & release kinetics compared with the reference brand. It was concluded from the study that most of the formulations were equivalent and there was no intra and inter variation between each and every formulation.

About the Author

Mr. Jayanta Kishor Chakrabarty hailing from Comilla, Bangladesh, obtained his M.Pharm degree from Dept. of Pharmaceutical Technology, University of Dhaka. Now he is employed in Northern University Bangladesh (NUB) as a Lecturer. He is interested to build his career in reseach sector.