Optimal Design for Nonlinear Response Models (Chapman & Hall/CRC Biostatistics)

Fedorov, Valerii V.; Leonov, Sergei L.

ISBN 10: 0367379805 / ISBN 13: 9780367379803

Published by CRC Press, 2019

About this Item

Seller Inventory # I-9780367379803

Bibliographic Details

• Title: Optimal Design for Nonlinear Response Models (Chapman & Hall/CRC Biostatistics)
• Publisher: CRC Press
• Publication Date: 2019
• Language: English
• ISBN 10: 0367379805
• ISBN 13: 9780367379803
• Binding: Soft cover
• Condition: New

About this title

Synopsis

Optimal Design for Nonlinear Response Models discusses the theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. The book draws on the authors’ many years of experience in academia and the pharmaceutical industry.

While the focus is on nonlinear models, the book begins with an explanation of the key ideas, using linear models as examples. Applying the linearization in the parameter space, it then covers nonlinear models and locally optimal designs as well as minimax, optimal on average, and Bayesian designs. The authors also discuss adaptive designs, focusing on procedures with non-informative stopping.

The common goals of experimental design―such as reducing costs, supporting efficient decision making, and gaining maximum information under various constraints―are often the same across diverse applied areas. Ethical and regulatory aspects play a much more prominent role in biological, medical, and pharmaceutical research. The authors address all of these issues through many examples in the book.

About the Author

Valerii Fedorov, PhD, is Vice President of Predictive Analytics, Innovation at Quintiles.

Sergei Leonov, PhD, is a Senior Principal Scientist at AstraZeneca.