Optimization In Drug Discovery In Vitro Methods 2Ed (Hb 2014)

Caldwell

ISBN 10: 1627037411 / ISBN 13: 9781627037419

Published by Humana, 2013

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Bibliographic Details

• Title: Optimization In Drug Discovery In Vitro Methods 2Ed (Hb 2014)
• Publisher: Humana
• Publication Date: 2013
• Language: English
• ISBN 10: 1627037411
• ISBN 13: 9781627037419
• Binding: Hardcover
• Edition: 2nd Edition
• Condition: Brand New

About this title

Synopsis

Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve “drug-like” characteristics in addition to efficacy properties and good safety profiles of drug candidates.

Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.