Oral Gastroretentive Floating In-Situ Gelling System of Furosemide: Controlled Release Dosage Form

Alhamdany, Anas T./ Maraie, Nidhal K.

ISBN 10: 6202066792 / ISBN 13: 9786202066792

Published by LAP LAMBERT Academic Publishing, 2017

About this Item

148 pages. 8.66x5.91x0.34 inches. In Stock.

Seller Inventory # zk6202066792

Bibliographic Details

• Title: Oral Gastroretentive Floating In-Situ Gelling System of Furosemide: Controlled Release Dosage Form
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2017
• Language: English
• ISBN 10: 6202066792
• ISBN 13: 9786202066792
• Binding: Paperback
• Condition: Brand New
• Weight: 0.27 kilograms

About this title

Synopsis

Floating in-situ gel is one of the gastroretentive drug delivery systems represents a revolution in the oral controlled release dosage forms in comparative with conventional oral liquids. They prolong the residence time of the drug that has a narrow absorption window in the absorptive sites like stomach or upper gastrointestinal (GI) tract; since they have a bulk density lower than gastric fluids. Thus they remain buoyant in the stomach without affecting the gastric emptying rate until all the drug release continuously at a slow rate. Furosemide is a high ceiling loop diuretic widely used for patients with congestive heart failure (CHF) to get rid of excess body water, reducing blood pressure, and mobilizing edemas. This study involved formulation of furosemide oral solution which undergoes gelation upon direct contact with gastric fluid and floated using either primary polymers as sodium alginate and gellan gum or in combination with secondary polymers as iota carrageenan and HPMC. Different evaluations were performed on all 35 in-situ gel formulas to measure the gel strength, gelation time, swelling index, content uniformity, floating lag time, floating duration, pH and density.

About the Author

Anas Alhamdany has completed MSC from College of Pharmacy, Al-Mustansiriyah University, Baghdad, Iraq. Now he is working as academian and researcher in the same college. Co-author - Prof. Dr. Nidhal K. Maraie who has a number of publications in various national and international journals also has a wide experience in the nano pharmaceutical field.