Organ Crosstalk in Acute Kidney Injury: Basic Concepts and Clinical Practices

This is an original work dedicated to an important and current topic in nephrology: organ crosstalk in acute renal injury.

Acute kidney injury is a prevalent and serious syndrome. The related mortality to this syndrome has not been significantly reduced in the last decades despite the advances in renal replacement therapy technology. For this reason, a new approach to obtain an effective treatment is urgently needed. The organ crosstalk perspective could be useful in order to achieve this objective since it implies a very early acute kidney injury diagnose and treatment.

This book includes a comprehensive review of the organ crosstalk perspective in acute kidney injury. Organized in two parts, the chapters in the first part present general subjects as an introduction to analysing the crosstalk concept. These chapters give an overview of the concepts of biosemiotics, hormones, neurotransmitters, cytokines, signalling and adhesion molecules, organ intercommunication, and epigenetics. The second part gathers chapters on the different kidney crosstalk, such as brain, lung, heart, liver, gut, and placenta. Finally, there is a chapter dedicated to the influence of renal replacement treatment on kidney crosstalk.

Since acute kidney injury is a topic of interest to many health professionals, this work will be a useful resource to general practitioners, internal medicine physicians, geriatricians, nephrologists, critical care therapists, immunologists, and also biologists and bioengineers.

Carlos G. Musso, MD PhD

He is Medical Doctor (Gold medal) - University of Buenos Aires (1991), Medical Specialties: Internal Medicine and Geriatrics (1996) - Nephrology and Internal Milieu (1998), Nephrology fellow in University Hospital of Salamanca, Spain (1999), Nephrology fellow in Toronto Western Hospital, Canada (2002). Doctor in Medicine (Cum Laude) - University of Salamanca, Spain (2011), Head of Clinical Renal Physiology - Head of Peritoneal Dialysis Divisions at Hospital Italiano de Buenos Aires, Argentina, Researcher of Ageing Biology Unit, Hospital Italiano de Buenos Aires -IAGG Research Network, Associated Editor - Electronic Journal of Biomedicine, Full Professor of Human Physiology - Instituto Universitario Hospital Italiano de Buenos Aires, Argentina

He has published 500 original and review papers in peer-reviewed journals, 5 books and 15 chapters. The current Index H is 28 and Index i10 is 76.

 Adrian Covic, MD PhD

He received a PhD on: “Cardiovascular abnormalities and its determinant factors in chronic renal failure” in 1997. Since 2007, he is a FRCP (London) and became a member of the Romanian Academy of Medical Sciences in 2009 and a FRCP (Edin.) in 2018. Professor of Nephrology and Internal Medicine at the “Grigore T. Popa” University of Medicine and Pharmacy, the Director of the Nephrology Clinic and the Dialysis and Transplantation Center in Iasi, Romania. He served as President of the Romanian Society of Nephrology and Secretary Treasurer of ERA-EDTA. Editor in Chief (Nephrology) for the International Journal of Urology and Nephrology. Vice-Rector (Research) of the University of Medicine “Grigore T. Popa” Iasi, Romania and a board member of KDIGO, ERBP, and ERA-EDTA working groups – EURECAM and EUDIAL.

 He has published more than 450 original and review papers in peer-reviewed journals, 16 books and 22 chapters. The current Hirsch index is now 62

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