Organ-On-Chip

Organ-on-chip (OoC) technology, also known broadly as microphysiological systems (MPS), represents one of the most consequential methodological advances in biomedical science of the past two decades. By recreating the essential structural, mechanical, and biochemical microenvironment of human tissues on microfluidic devices no larger than a memory stick, these systems promise to bridge a long-standing gap between traditional two-dimensional cell culture and the enormously expensive, ethically fraught, and frequently unreliable use of animal models in preclinical research. This book surveys the scientific foundations, engineering principles, organ-specific implementations, industrial landscape, regulatory context, and future trajectory of organ-on-chip technology, with particular emphasis on its transformative role in drug discovery and toxicological safety assessment. It is intended for graduate students, academic researchers, regulatory scientists, and industry professionals seeking a rigorous yet accessible synthesis of a rapidly evolving field.